phuluong2k
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I think it's mecanism is unclear
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| dr.vasim
Forum Senior
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yeah.but.for.sure.there.must.b.some.PATHOPHYSIOLOGY.
what.i.know.is.itz.COZ.of.Chronic.HYPOXIA...
rest.if.some1.explains..wil.b.gr8ful
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| bhagat
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The hypoxia stimulates blood vessel formation via gene expression, soft tissue deposition, and interstitial edema causing the bulbous enlargement. Also i believe ferritin or ferric ions have a role in the genesis. The actually cause in unknown, but there may be an unknown humoral substance involved.
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| Renegade
Forum Elite
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This article blames megakaryocytes. I also heard chronic PO2 changes at the level of the nailbed were to blame, and in cirrhosis mere lung compression was enough to cause these changes, thus leading to clubbing.
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| dr.vasim
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thanx guyz...both bhagat & Renegade. I appriciate it.
but still its xact mechanism is in dilemma. 
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| ARJ
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Goljan mentioned the pathophysio of clubbing but I am not able to recollect ?????????
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| kal_9980
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clubbing is probably caused by hypervascularity and opening of anastomotic channels in the nail bed due chronic hypoxic conditions andthe grades of clubbing are due severity of chronic hypoxic conditions
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| dr.vasim
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gr8 KAL..but r sure its same given in kaplan too?
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| kal_9980
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its wat i learned in my clinicals
not sure abt kaplan
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