batman
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What are the layers and structures located between the blood plasma and brain interstitial fluid? (I think they are astrocytes and continuous capillaries, but I'm not sure)
What are the layers and structures between the blood plasma and the cerebrospinal fluid?
Of the Cerebrospinal fluid, interstitial fluid, blood plasma and intracellular fluid, which fluid normally has the most dissolved protein? Which fluid normally has the least dissolved protein?
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| mildus
Forum Guru
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the Blood brain barrier (BBB) is an endothelial barrier:
1. tight junctions between the endothelial cells of continuous capillaries (these junctions are the most important part of the BBB; that is why the BBB is an endothelial barrier)
2. lamina limitans of perivascular glia (astrocytes)
The Blood-CSF barrier is an ependymal barrier:
1. fenestrated capillaries
2. interstitium
3. tight junctions between the ependymal cells (this is the most important part of the barrier, so the blood-csf barrier is an ependymal barrier)
So, we can see that plasma freely goes out from the capillaries (fenestrated capillaries have many holes so they are no barrier), and the ependymal cells "decide" which substances will go into the CSF by way of transcellular transport.
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| mildus
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The blood contains proteins in concentration of 60 - 80 g/L, but the CSF has almost none.
This is one of the reasons for plasma having higher buffer capacity than the CSF.
The CSF is often considered to be the brain interstitial fluid.
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| batman
Forum Newbie
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Thanks!
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