dr in trouble
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name 3 drugs used for alcohol withdrawl?
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| drkpp
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disulfiram, acamprosate and diazepam
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| ARJ
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Chlordiazepoxide ( Librium) and the Benzodiazepines which does not pass through C 450 enzyme through Liver, ie Oxazapam, lorazepam, Tamazepam.
Chlordiazepoxide ( Librium) is consider to be the best drug in prevention of withdrawl.
Also, one more drug call TRANXENE. I would like to know about it.
Disulfiram is used to prevent relapse rather then in the treatment of withdrawl
drkpp I would like to know MOA of Acamprosate and how it would be helpful
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| drkpp
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Acamprosate does not have a direct effect on acute alcohol withdrawal, but is thought to reduce the ‘craving’ that is experienced by alcohol dependent patients. Acamprosate has a chemical structure similar to that of amino acid neurotransmitters such as gamma-amino butyric acid (GABA) and glutamate, and evidence suggests that it acts by stabilising the imbalance of neurotransmitters which is seen in alcohol dependency. Treatment should therefore be initiated promptly following alcohol withdrawal and continued for one year in conjunction with counselling. Treatment should be maintained if the patient relapses.
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| drsnq
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Lomepizole...which inhibits alcohol dehydrogenase enzyme...
disulfiram..inhibits acetaldehyde dehydrogenase
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