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neoplasm
Forum Senior

Topics: 11
Posts: 27

09/26/05 - 08:31 AM

A 40 year old has recurrent Ca calculi..decreased by

Administration of thiazide

Alkalization of urine

ingestion of high oxalate

ingestion of high protein

restriction of fluid intake

the_holy_man
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09/26/05 - 11:21 AM

Thiazide

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neoplasm
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Topics: 11
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09/26/05 - 11:37 AM

thiazide causes hypercalcemia..i dont agree with you holy man...please help me out...had this Qs in nbme.. shaking head

drkpp
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Topics: 45
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09/26/05 - 11:45 AM

hey neoplasm, ever thought why thiazides cause hypercalcemia!!!!!!!!!!!!

if u figure that out u will also come to know that holyman was indeed correct.. grin

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the_holy_man
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09/26/05 - 01:09 PM

Thiazide cause increased calcium reabsorption.So it cause hypercalcemia and low calcium in renal tubules which decreases risk for ca calculi.
Same principle applies when they give thiazides to old ladies with osteoporosis as it increases plasma calcium level. smiling face

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drkaur
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09/27/05 - 12:59 PM

thiazides

usmlegr
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09/30/05 - 05:14 PM

theazides lower calcium excretion, people!!!!!
I'd go with "ingestion of high protein"

ssrpk
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10/03/05 - 11:35 AM

thiazides is correct!

"usmlegr" - thiazide reduces excretion mainly via increased reabsorption from renal tubules (DCT- as exlained by holy man)

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usmlegr
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10/03/05 - 03:19 PM

ssrpk wrote:
thiazides is correct!

"usmlegr" - thiazide reduces excretion mainly via increased reabsorption from renal tubules (DCT- as exlained by holy man)

silly me

, i read "caulcili...caused by" instead of "decreased by". I must be more carefull in actually reading the question. I get carried away very easily and skip important words. mad

edit: If i read even more carefully i would have seen that both "ingestion of high protein" and "restriction of fluids" cause renal calculi. Damn, i must have a concentration disorder or something. It's really stupid to miss questions that you know.

ssrpk
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10/04/05 - 10:23 AM

#10

it happens, just be careful smiling face

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gpsbrar
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Topics: 34
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10/05/05 - 01:37 PM

#11

Thiazides are given. I would pick coz there is only one DIURETIC. But now the problem is still there that the calcium with still there and it would it is reabsorbed again in DCT. But the filtration will be in the glomerulus and the stone formation will start i the glomerulus. Please anyone explain me. I suck in Renal pathology concepts. No matter howmuch I read I mess it up all the time with my out of no-where logics.
Plus I have read 1000 times (Use of Hydrochlorothiazides reduce the calcium oxalate stone) and never understood the mechanism. Is there any simple way of remembering it or I just have to cramp and memorize it as I did earlier. Please Please and Please help me understanding it.

Edited by gpsbrar on 10/05/05 - 01:44 PM

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jassi
Forum Newbie

Topics: 1
Posts: 5

10/05/05 - 07:34 PM

#12

hi gps brar

try reading katzung pharma for this topic .that might help u

just a advice

gpsbrar
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Topics: 34
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10/05/05 - 08:24 PM

#13

thanks jassi I have kaplan or Lippincots pharmacology. I shall try may be they have in barne's and Noble's.

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dharjma
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Topics: 11
Posts: 182

10/18/05 - 09:16 PM

#14

ok this is how it works i think. In early distal convulated tubule, Na and Ca ions share the same channel for reabsorbtion. since thiazides blocks Na and Cl reabsorbtion, this leaves the channel free for Ca to utilise, this increases Ca reabsorbtion.
do remember that Ca reabsorbtion at this site is PTH dependent meaning it only occurs when PTH is released. (which is in contrast to asc Loop of Henle where Ca reabsorbtion is NOT PTH mediated.)

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