step1mom
Forum Senior
Topics: 32
Posts: 64
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Hi
I have been listening to kaplan lectures.About the mechanism of intreferons,I have a confusion.Is it that interferon alpha and beta inhibit the host cell rna from synthesizing proteins that virus needs from us OR they inhibit viral protiens?If they does inhibit viral protiens then what is the mechanism?plz answer.
Thanx
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| vallia
Forum Guru
Topics: 98
Posts: 889
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Hi mom
Interferon alpha (leucocyte interferon) and interferon beta (fibroblastic interferon) are made by a cell when infected with a virus. The interferons are released from the cell (which usually die from infection) and binds to the target cell.
here they induce the production of some proteins( 20-30 proteins) and that proteins give the anti viral state. Particularly 3 proteins are important
1. 2'5'oligo A syntase
2. the second is a ribonuclease induced by 1. that can break down the mRNA
3. the third is a protein kinase named eIF2 induced by 2. that inhibit initiation of protein syntesis
These activities target viral protein syntesis but can also inhibit host protein syntesis so this proteins must be activated only when they needed. In the interferon treatment inactive forms of proteins are induced, which are activated by the presence of a virus (activation requires double stranded RNA)
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