reet
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genomic imprinting---prader willi from dad ,,angelman from mom...but in RELF ,,how can we predict which one is present?
anyone explain?????????where inactivation or methylation is occuring???????????????
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| reet
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how methylation work here???
Edited by reet on 09/09/05 - 05:49 PM
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| cyra
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Reet....i am confused...could you may be rephrase the question?From what i know prader willi syndrome is due to a deletion in the paternal chromosome 15...while angel man syndrome is the result of a deletion in the maternal chr 15.
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| reet
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cyra,, its ok 15 chromosome deletion but how can we tell its from mom or dad?wht actually they perform to know the facts?
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| an
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methylation patterns detected by southern blot or by PCR using DNA primers that can detect methyalted cytosine...
to diagnose if it's due to uniparental disomy, u use markers from both chr 15 of both parents and detect presence in the patient
FISH if deletion of 15q suspected
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