usmlebuzz
Forum Elite
Topics: 93
Posts: 263
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A 17-year-old female presented with a malar rash that worsened on sun exposure. The patient also complains of joint stiffness and pain involving her ankles, wrists and knee joints. On further questioning, she described a feeling of weakness, anorexia and weight loss. She also gave a history of hematuria.
Lab investigations revealed anemia, neutropenia and thrombocytopenia. Tests for antibodies are likely to reveal auto-antibodies against
A Small nuclear ribonucleoproteins
B DNA molecule
C Histones
D Ribosomal proteins
E Nicotinic acetylcholine receptors
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| MIG
Forum Junior
Topics: 6
Posts: 63
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PROBABLY B AGAIN
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| usmlebuzz
Forum Elite
Topics: 93
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sorry again try once more
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| Bonnie_K
Forum Newbie
Topics: 2
Posts: 11
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Hmmm,
Looks like systemic lupus erithematosus.And most specific for it is antibodies to double-stranded DNA.
Ok, next specific is antibodies to ribonucleoprotein.
Is it A ?
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| Yulia
Forum Elite
Topics: 19
Posts: 240
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I saw this one in exam master sample questions...
they want us to choose a - Small nuclear ribonucleoproteins. I honestly don't know why. The question sounds like they are looking for most sensitive a/b (most likely to be there), which would be ANA, and it's not on the list.
and if that's supposed to be most specific a/b, that would be anti ds dna as bonnie said. but that's listed as the wrong answer...
ritu, can you explain why a would be the right answer here?
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| usmlebuzz
Forum Elite
Topics: 93
Posts: 263
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you r right yulia
this is a question from exammaster the only reason I posted it coz I was unable to understand why A should be right??????????
Hope , somebody else can clarify our doubt :roll: 
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