usmlebuzz
Forum Elite
Topics: 93
Posts: 263
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DIC may be caused by:
release of thromboplastin into the bloodstream
obstetrical catastrophe (thromboplastin from placenta)
major tissue injury (burns, heat stroke, surgery, trauma)
acute promyelocytic leukemia (thromboplastin from "pro"'s granules)
mucinous adenocarcinomas (mucin activates factor X directly)
sepsis (thromboplastin from PMN's)
snakebite
endothelial damage
vasculitis (especially malignant hypertension, meningococcemia, rickettsial disease)
Kasabach-Meritt syndrome (giant hemangioma with ongoing "localized DIC" inside)
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hypothermia (as in cardiac surgery: poorly understood.
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