vic2005
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can someone tell me the lesion in which part of the brain will affect old memories ? And the types of memories?
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| mildus
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thalamus - retroactive amnesion
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| gpsbrar
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Please can you expand the explanation for both retro and antegrade amnesias and their mechs. Please....
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| mildus
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Morfological substate for memory are engrams. There are two kinds of engrams:
1. functional or dinamical (representing the short term memory) which are stored in hippocampus
2. structural engrams (representing the long term memory) which are stored mostly in thalamus.
Hippocampus has two important roles:
1. it stores dinamical engrams of short term memory
2. it decides whether information is important enough to be stored for long term (hippocampus converts dinamical engrams to structural engrams i.e. it converts short term to long term memory)
Thalamus is a place where structural engrams are stored.
Two kinds of amnesia:
1. anterograde - due to hippocampus damage there is a loss of short term memory and short term memory can't be converted to long term memory i.e. you can't memorise anything, but you remember all the things which were memorised before damage because thalamus is o.k.
2. retrograde amnesia - due to thalamus damage there is a loss of long term memory because structural engrams are destroyed, but the short term memory is unaffected because hippocampus is o.k.
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| gpsbrar
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thanks bro. great help.
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| gpsbrar
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it was so simple and easy. I don't know why I had hard time understanding it. U have a nice understanding about the concepts. Thanks again.
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| ssrpk
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hey boy! tht's a great info, did'nt realize it was so easy!
but can you give some details regarding the thalamic nuclei tht may be associated with memory consolidation! i did'nt know any, i know 3 thalamic nuclei that has some role to play in limbic circuits! but are they also involved in memory consolidation as well?
thanks
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| mildus
Forum Guru
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I'm sorry but I don't know, I haven't seen anywhere
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| vic2005
Forum Senior
Topics: 32
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Thank you guys for the replies . I think the nucleus involved in memory is the dorsomedial ( it is connected to the prefrontal cortex ) and when you have a lesion in it you may present with memory loss ( based on the explanations from you ,i guess the long term memory is impared because the short term memory is related to hippoccampus)
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| twinkle
Forum Senior
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And  the receptor involved in the learning process in the hippocampus is N-Methyl-D-Aspartate( NMDA) receptor.
It`s a glutamate receptor.
(Gets hyperactive in Huntington`s Disease.)
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| mildus
Forum Guru
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yes, that NMDA receptor is a miracle - both for health and disease
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