chemamr
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Tell all the differences between bullous pemphigoid and pemphigus vulgaris
Age
Clinical findings
Biopsy
Immunofluorescence
Antibodies
Treatment
 This is a topic that i often get confused.
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| nisha
lil monkey
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Pemphigus Vulgaris
- age: 30-40yrold
- clinical findings: denuded skin with fragile suprabasal blisters which rupture easily, may see oral lesions
- biopsy:acantholysis, separating of the epidermal cells
- immunofluorecence:antibodies to antigens in epidermal intercellular spaces(desmosomes attacked)
- antibodies: IgG (C3 deposition also seen)
Bullous Pemphigoid
- age: 70-80yrs
- clinical findings: tense subepidermal bullae, often intact, denuded eroded areas, no involvement of oral mucosa
- Biopsy: entire epidermis lifting up and separating from dermis, deeper blisters at dermo-epidermo junction
- immunofluorescence: antibodies at the dermo-epidermal junction(hemidesmosomes)
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| chemamr
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thatīs correct Nisha.
I must add something for you: in bullous pemphigoid there are 2 specific antibodies that you must know: antiBP230 and antiBP180 
Thanks you for your reply
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