KEROCHI
Forum Guru
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A young boy c/o degenerative joit pains. Blood test reveal Normal CBC, N RF. urine sample collected turns black on standing. What is deficient in this pt?
a.hemoglobin
b. deaminase
c. homogentisic acid
d. HGPRtase
E.immunoglobin G
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| ssrpk
Forum Fanatic
Topics: 154
Posts: 2,819
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TYPO!!!
homogentisate oxidase is def. in oochronosis ,therefore homogentisate acid accumulates!
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| KEROCHI
Forum Guru
Topics: 60
Posts: 971
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correct..
however spelling is correct too!
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| KEROCHI
Forum Guru
Topics: 60
Posts: 971
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Condition is Alkaptonuria( Ochronosis) caused by a deficiency of homogentisic acid oxidase (homogentisate 1,2 dioxygenase). In this condition, homogentisic acid, an intermediate in the catabolism of tyrosine, accumulates in cells & body fluids including spinal fluid & urine.
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| chemamr
Forum Hero
Topics: 703
Posts: 4,461
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yes, alkaptonuria by accumulation of homogentisic acid. Urine is black, also cartilages (ear) turns dark.
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| jvo_md
Forum Senior
Topics: 22
Posts: 189
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C is the answer...Alkaptonury
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| Cedrick
Forum Fanatic
Topics: 322
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good question,the first time I heard about this Isaid it can't be so I remmeber this one
yes C
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| Cedrick
Forum Fanatic
Topics: 322
Posts: 1,975
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