sethigulshan
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| GMOB
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we have 3 layers: molecular, purkinje and granular. We have different cells: stellate, basket, granule, purkinje, golgi. we have 2 great input fibers: mossy and climbing. All cells use GABA and are inhibitory, except for Granule cells that use glutamate and is excitatory. The only output of the cerebellum is through axons of the pukinje cells.
These are just some data on that histo, i didnt really understand your question though...
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| sethigulshan
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So what do you think are the components of the Molecular layer?
Lets do it this way?
Outer most layer in Cerebellum is the Cerebellar Cortex or the Grey Matter and the innerlayer is the white matter.
Cerebellar cortex inturn has 3 layers,
outermost is Molecular layer, Inner to it is the Pirkinje cell layer and the inner most layer of the cerebellar cortex is the Granule cell layer.
to start with,lets take the Pirkinje Cells, so if you can mentally visualise, its dendrites are going to be in the layer outer to it ( molecular layer).
You said that the output of the cerebellum is axons of Pirkinje cells, but I think you must check it, what I can get is that Pirkinje axons leave the Cerebellar Cortex ( not the Cerebellum) The output of the Cerebellum is thru the deep cerebellar nuclei of which Dentate is the most important, the others are Fastigius, Globoform and ??( oops I forgot). You can remember it thru the dentatothalamic tract which goes to the contralateral thalamus.
So what about the granule cells, these cells have their axons in the molecular layer ( parallel fibres ) which synapse with the dendrites of the Pirkinje cells. of course they are excitatory at the synapse with glutamate being released. Lets make a correlation that just got into my mind, what about the newer anticonvulsants , I think I forgot is it Topiramate that competitively blocks the action of glutamate on the AMPA receptors, I dont remember exactly, I will have to check that. and GABA potentiaters, Tigabine, Lamotrigine. Please make me correct!!
Lets get back to the story of Cerebellum.
2 types of fibes, Mossy fibres and Climbing fibres.
Climbing fibres are the fibres that connect with the inferior olivary nucleus of the Medulla. Rest everything that comes or goes is Mossy fibres.
Do you agree with whatever I mentioned. Just correct me if I am wrong anywhere.
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| mildus
Forum Guru
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Sethigulshan I think everything you said is correct and very well explained (I just don't know anything about those drugs and receptors).
Just to add that climbing fibres are important for motor learning because they change Purkinje cells' sensitivity to signals coming from mossy fibers.
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