mildus
Forum Guru
Topics: 19
Posts: 614
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As far I know, ApoE is to recognize the receptors on hepatocytes. That is the way how VLDL, IDL, LDL can be returned to hepatocytes. 
And can you list those "clear functions of apoAI,CII,B100,B48" ?
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| ssrpk
Forum Fanatic
Topics: 154
Posts: 2,814
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chylomicron uptake is mediated by APO-E, not APO-B48 (think dysbeta lipoproteinemia)
APO-B48 is synthesized by intestinal epithelials for lipoprotein assembly which in true sense is similar to APO-B100 except for the fact tht it is comprised of only 48% of mol.wt. of the original APO-B100 (tht's why APO-B48) ;the molecular part tht are missing in APO-B48 is responsible for the uptake by hepatocytes therefore LDL receptor can ony identfy APO-B100 and APO-B48 only has structural role to play in chylomicrons!
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| bluecatback
Forum Elite
Topics: 57
Posts: 48
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Thanks a lot!
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