sethigulshan
Forum Senior
Topics: 27
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Allopurinol, is contraindicated in Lesch Nyhan patients ? Why
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| kingsofke
Forum Guru
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probably because it would result in built of Inosine monophosphate which offcourse is not being salvaged and you give allopurinol and it would not even be degraded.
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| sethigulshan
Forum Senior
Topics: 27
Posts: 146
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ya, you are right. There is another story to it. Allopurinol is an analog of purine, it requires the enzyme PR Transferase, so that it can form (Phospate+Ribose+ allopurinol )and that way it can inhibit the denovo synthesis of the purines.
Of course it also acts at xanthine oxidase.
What do you think?
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| ssrpk
Forum Fanatic
Topics: 154
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which drug when co-administered with allopurinol requires dose reduction?
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| kingsofke
Forum Guru
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which offcourse is metabolised by Xanthine Oxidase  6 Mercaptopurine ?
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