mildus
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What would happen to cell if Na/K ATPase stopped working?
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| mesh
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The cell's resting membrane potential is a manifestation of the electrical gradient, and the gradient is the basis for excitability in nerve and muscle cells.
Export of sodium from the cell provides the driving force for several facilitated transporters, which import glucose, amino acids and other nutrients into the cell.
Translocation of sodium from one side of an epithelium to the other side creates an osmostic gradient that drives absorption of water.
all these functions are regulated by the pump....failure will lead to failure of all these.....
a stage of sustained contraction will be there.....
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| ssrpk
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"a stage of sustained contraction will be there..... "
Can you elaborate this?
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| mildus
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I agree. So the cell volume increases...
and why does sodium drag water and potassium doesn't?
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| ssrpk
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Na+/K+ pump is also known as electrogenic pump, as it pumps 3 Na+ ions outward for each 2 K+ ions inward, thus creating a cation deficit in the cytoplasm (-ve RMP); however as cell injury occurs which result in depletion of ATP ,the Na+ accumulates in cytoplasm and resulting osmotic gradient pulls in water causing cellular swelling!
Potassium flux is directred outwards so it will not be a/s with significant osmotic change inside the cell!
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| mesh
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there will be increased intracellular calcium due to blockage of the pump.....so it will lead to sustained contraction.....
correct me if i am wrong....
will there be a stage of hypocalcemia ?......
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| ssrpk
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first of all, realize tht Na+/K+ pump depends upon ATP which gets depleted only after ischemia or injuryt or death! in these circumstances Ca++ will accumulate because of inhibition of Ca++ pump on sarcoplasmic reticulum, which can result in a state of suatained contraction [rigor mortis] without the generation of active tension!
however in herat inhibting the pump reverses the Na+/Ca++ exchanbger and inc. IC Ca++ iopn conc. and cause inc. force of contraction! but here there will no sustained contraction due to relatively longer refreactory period!
i dopn't think there will be any hypocalcemia primarily due to this loss of Na+/K+ pump!
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