ayeshah_l
Forum Elite
Topics: 29
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y B blockers are given in prevention of E. varices? whats the mech. of action?
and y octreotide is given in bleeding E. varices? whats the MOA?
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| Vai
Forum Elite
Topics: 30
Posts: 195
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because unselective b blockers( beta 1&2) like propanolol lower portal hypertension, selective one have no action ( e.g. metoprolol), i know from my work i didn't read it anywhere
about octeotride i go to read something
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| mani
Forum Guru
Topics: 104
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beta blockers as well as nitrates lower the portal pressure. so both r useful in prevention
octreotide diminishes blood flow to portal system due to vasoconstriction, thus decreasing variceal bleeding
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| ruhighazi
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Non-selective beta blockers (eg, propranolol and nadolol) block the adrenergic dilatory tone in mesenteric arterioles resulting in unopposed alpha adrenergic mediated vasoconstriction and therefore a decrease in portal inflow. At the present time, these are the only drugs recommended for prophylaxis against a first variceal hemorrhage.
Somatostatin and its analogue, octreotide, are direct splanchnic vasoconstrictors leading to diminished blood flow in the portal venous system.
IV infusion of vasopressin results in generalized vasoconstriction leading to diminished blood flow in the portal venous system. Control of bleeding can be achieved in up to 80% of cases, but bleeding recurs in more than half after the vasopressin is tapered and discontinued.
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| ayeshah_l
Forum Elite
Topics: 29
Posts: 284
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thankyou to everyone who answered. It helped at lot.
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