hgheith
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If a pt had Vit D toxicity, along with hypercalcemia, would the pt be in a stuporous state? If not what would cause hypercalcemia and stupor?
Thanx
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| ssrpk
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i can only think of metabolic acidoisis which is related to hypercalcemia ,as met.acidosis depresses neuronal activity!
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| hgheith
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Can you explain that? I don't really get it, and would the acidosis cause stupor?
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| ssrpk
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sorry buddy my mistake! it's hypercalcemia tht leads to decreased neuronal activity ,met.acidosis does so too but by inc.free Ca++ levels in the blood!
in any event whether there is hypercalcemia or high free Ca++ (acidosis) ,neuronal activity will be depresed partly due to the fact tht high Ca++ levels prevents ful excitation of votage gated Na+ channels in neuronal memebranes and thterefore permeability of Na+ is reduced and so is the excitability!
am not sure abt stupurous state just due to hypercalcemia, but this factor (inc. Ca++) is additive!
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| ssrpk
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http://www.prep4usmle.com/forum/thread/20717
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| hgheith
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Thank you, but do you know the symptoms of hypervitaminosis D? and would stupor be part of that? thank you
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| ssrpk
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i am not sure about stupurous state but metastatic calcification and stone formation will occur
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