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Kaplan Qbank USMLE



Author7 Posts
  #1

Why does heterozygous females for G6PD def. have increased resistance to malaria? And why is the def. seen more commonly in families from regions where malaria is endemic? Pag. 202 Biochemistry book.

  #2

G6PD df. is an x-lined recessive disorder ,therefore females are heterozygus and do not express the disease however their rbc's hv so marginal supply of G6PD tht they do'nbt support growth of microbes and these induviduals show resistance to falciform malaria!

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life is guud

  #3

i thought only sickle cell anaemia has resistance to malaria ,does g6pd deficiency also have malaria resistance????

  #4

yeah and don't be surprised, even thalessemia trait has! shocked

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life is guud

  #5

Ok, thatīs a good point. I didnīt know it.

Resistance to malaria: SCD, G6PD defic and thalassemia trait. nod


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Any time something is written against me, I not only share the sentiment but feel I could do the job far better myself.

  #6

what abou the endemic area? Ab related?sad

  #7

I think its just the principle of 'natural selection' coming into play here. ...the same is true for population with SC and malaria (both endemic in parts of Africa)

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Courage does not always ROAR. Sometimes courage is the quiet voice at the end of the day saying, "I will try again tomorrow" - Mary Anne Radmacher







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