studentdoc
Forum Senior
Topics: 14
Posts: 33
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Can someone please explain exactly how this works. We learned this, but I'm not sure I understand the exact reason (T depend. vs indep, etc.)
thanks
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| son64
Forum Elite
Topics: 34
Posts: 245
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Inorder for a vaccine to be a T-cell dependent,it should have a peptide component.The reason is because the T-cells recognize only antigens with a peptide component presented to them on the the groove of mhc II of antigen presenting cells.The H.influenzae capsule is composed of polyribitol,which is not a peptide.So it has to be attached with a peptide like diphteria or N.meningitidis outer membrane proteins.
Hope it is clear!
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| ssrpk
Forum Fanatic
Topics: 154
Posts: 2,796
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if i remember correctly the same thing is done for pneumococcal 23 serotype vaccine!
can some confirm it?
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life is guud
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| studentdoc
Forum Senior
Topics: 14
Posts: 33
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Thanks. I almost gave up (didn't get an answer for a while) so thanks for your feedback.
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