monterusca2004
Forum Junior
Topics: 7
Posts: 42
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Why decreasing extracellular sodium concentration increases myocardial contractility
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| mildus
Forum Guru
Topics: 19
Posts: 614
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I don't know.
I know for hypocalcemia. It is not so important for the heart, because before the heart feels some problems (decreased contractility...), the man would die of asphyxia (because hypocalcemia increases excitability of respiratory neurons and musles so they can fall into tetanus)!
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| cyra
Moderator
Topics: 29
Posts: 844
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The myocardial cell has a Na-Ca exchange(a mechanism that moves calcium out of the cell)...the wroking of this depends upon the NA gradient....when ecf Na is diminished Na- Ca exchange cannot take place..that is Na cannot go into the cell and Ca cannot be extruded..therefore...incresing intracellular CA and the contractility....hope that helped...GL!
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| monterusca2004
Forum Junior
Topics: 7
Posts: 42
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Thank you, cyra, it did help me,
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