mjl1717
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What is the difference between Cushing Disease and Cushing Syndrome. Also when is ACTH increased and specifically would the androgens ever be increased??
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| 99doc
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cushing syndrome is due to hypercortisolism of any cause(most common-long term glucocorticoid therapy).
excluding this most common cause,the cushing syndrome is divided into 3 types.pit.cushing(cushing disease),adrenal&ectopic cushing.also another classification is primary&secondary hypercortisolism.secondary is same as pituitary cushing.
ACTH IS DECREASED IN PRIMARY.(ADRENAL&ECTOPIC)
ACTH IS INCREASED IN SECONDARY.(IN CUSHING DISEASE)
regarding androgens i am not sure in cushing case.but they definately increase in 21OH-def&11-OH-def.,along with ACTH increase.
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| ssrpk
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well tht's a nice explanation.....
androgens will inrease in both of the cushing's (pituitary and adrenal), however tht will not be the case with exgenous administration of excess steroids..
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| 99doc
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i found Harison says ACTH increased in ectopic?
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| ssrpk
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it does get increase ... but in true sense it's ectopic ACTH ;a glycoprotein quite similar to the one secreted by pituitary!
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