mjl1717
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I know its multifactorial but what causes cleft lip and cleft palate embryologically?
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Smell the coffee! "Is That an Osler move??"
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| 99doc
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first of all it is imp to know how they develop.PALATE-A)intermaxillary segment forms when the medial growth of maxillary prominence causes the 2 medial nasal prominences to fuse in middle.this segment forms-PHILTRUM OF LIP,4 INCISOR TEETH,PRIMARY PALATE.
SECONDARY PALATE-from outgrowths of maxillary prominences called-PALATINE SHELVES.
anterior CP-palatine shelves fail to fuse with primary palate.
posterior CP-when palatine shelves fail to fuse with eachother&nasl septum.
anteroposterior CP-combination of above defects.
CLEFT LIP-maxillary prominence fail to fuse with median nasal prominence.
the underlying somitomeric mesoderm&neural crest fail to expand resulting in a persistent labial groove.
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