SDK
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Calculate total HCO3 reabsorption from following data..
Clearance of Inulin=3L/day
plasma HCO3=25mmol/L
urine HCO3=0
urine pH=5.8
Titrable acids in urine=26
nontitrable acids in urine=48
a)0
b)74
c)75
d)149
e)48
f)26
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| ssrpk
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well i am confused abt the data!
inulin clearnce reflects exactly the GFR.......it's just 3L/day tht's wayyyyy too low!
anyway if i jst follow the rule of thumb......
filtered load for HCO3-=GFR X P(HCO3)
= 3L/day X 25mmol/L
=75 mmol/day!(all of it has reabsorbed)
still! GFR of 3L is freaking me out! :shock:
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| att
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B.74
new H2co3 gain=total acid loss.
74=26+48.
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| ssrpk
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i think the q is asking abt reabsorption :shock: :|
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| att
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yes ,i think these new H2co3 will form and reabsorb and Acid will be secreted!
plz tell me which i,m thinking bwrong??
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| ssrpk
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i am confused too....but i still think it's abt reabsortion tht takes place in prox. tubule!
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| att
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lets wait for the ans by sdk.
i thinlk data is to make u confuse by giving extra information.
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| mle04
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Total Bicarb Reabsorption=Prox tubule + Distal Tubule
At Prox Tubule--Filtrn Load=GFR x Pl.Conc
3 x 25=75
At Distal Tubule--Titrable acid + Non titrable acid
26 + 48 = 74
So, Total Bicarb Reabs = 75 + 74
= 149..
I hope I am right.
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| ssrpk
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well tht's a 3rd possibility......too bad every one of it is among the options!
hey SDK whtz the answer!
and throw some light over this reabsorption issue!
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| att
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mle04 ur ans sounds complete.
as its asking Total Bicarbonate reabsoprtion
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| SDK
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Don't worry about the values but only think that what is asking......
I am just trying to clearify ur concepts about calculating problems......
So answer is 149 as write by mle04.... 8)
I didn't think that GFR is too low in this Qs.... :wink:
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