"step1mom" wrote:
3:What is frame shift mutation?
Frameshift : a base in mRNA is lost.and the next coming base takes its place, but the whole sequence changes because it is shifted to the left.
Example : GGU-GGA-UGA-GUU (mRNA)
deletion of the first guanine base results in -->
GUG-GAU-GAG-UU
completely different aminoacids will be coded from this sequence --> completely different protein .
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| purplepen
Forum Newbie
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Frameshift is a deletion or insertion of base(s) that change the coding sequence. As long as the deletion or insertion is not the mulitiple of 3, there will be a frameshift mutation.
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| anjushree
Forum Guru
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when deletion is in multiple of 3 ,it is called INFRAME mutation
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| reet
Forum Fanatic
Topics: 152
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example TAYSACS ds--4 base insertion
cystic fibrosis--- 3 base delition ( which is not frame shift)
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