mash
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Because of the shortage of donor organs, some researchers have experimented with xenotransplantation. Animal organs may substitute for diseased human organs. What is the major barrier to successful transplantation across animal species (xenotransplantation)?
A. Acute rejection
B. Chronic rejection
C. Hyperacute rejection
D. Infection
E. ABO incompatibility
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| mani
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A. Acute rejection
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| florida_dr
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i think correct ans. is c)hyperacute rejection
There are four immunological barriers that must be overcome for achieving successful organ xenotransplantation from pig to primate (human and non-human). First, hyperacute rejection, which is caused by xenoreactive natural antibodies and complement of the recipient acting against endothelial cells of the source animal organ. Second, acute vascular rejection caused by the combined effect of elicited xenoreactive antibodies and activated host natural killer cells and monocytes. In combination these stimuli (the anti-graft antibodies and the activated host cells) result in activation of the endothelial cells of the source organ. Endothelial cell activation leads to general inflammation with resultant thrombosis (platelet aggregation and activation of the coagulation cascade) resulting in organ rejection. Third, the xenograft counterpart of classical T cell mediated rejection of allografts (transplantation between individuals of the same species) will almost certainly occur. Finally, xenografts may also be subject to chronic rejection in a manner analogous to allografts.
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| chemamr
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I think itīs C (hyperacute rejection: antibodies against HLA or ABO, etc. and there isn't treatment for this )
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