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Kaplan Qbank USMLE



Author4 Posts
  #1

The destruction of H2O2 which is a mildly toxic reduced oxygen species, is catalyzed by which of the following enzymes?

1-cytochrome oxidase
2-catalase
3-nitric oxidase synthase (inducible)
4-superoxide dismutase
5-xanthine oxidase

  #2

2 catalase

  #3

i go for catalase too

  #4

I) H2O2 +"catalse" :arrow: H2O and 02

II) O2 +"superoxide dismutase" :arrow: H2O2

III) H2O2 +"myeloperoxidase"* :arrow: HOCl(bleach) +OH

*Myeloperoxidase is most potent and is a lysosomal enzyme.

Another distractor-cytochrome oxidase also called cytochrome a+a3.
In this complex reaction electrons, protons, Molecular Oxygen and porphyrin ring, Fe and copper produce water.

NO synthetase is increase in response to infections/ in the macrophage its calcium independent.(its stimulated by lipopolysaccharide/gamma interferon

*Glutathione peroxidase can neutralize catlase also!

Xanthine Oxidase -thats too easy. :idea:

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