jenni1
Forum Junior
Topics: 5
Posts: 12
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I have two question about Blood transfusion, please help to explain.
#1: Blood group AB are universal recipients. I'm not sure if it means blood group AB accepts all blood types of packed RBCs or whole blood. If it means whole blood, what happens if transfuse type O whole blood to blood type AB patients? Since blood type O serum have anti-A, anti-B IgM and anti-AB IgG, do the antibodies from serum of donor attach to recipient AB RBC and induce hemolytic transfusion reactions? If this is the case, it won't support AB is universal recipient.
#2 In Goljan's path rapid review, in chapter 15 blood transfusion therapy section, he mentions tests performed on donor blood includes antibody screen (indirect Coombs' test). Shouldn't antibody screen be test on recipient instead of donor? Is it necessary to test it on donor?
Thanks a lot!
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| phuluong2k
Forum Fanatic
Topics: 714
Posts: 2,008
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In transfusion there are 2 reations
1) Recipient antibody + RBC donor :arrow: hemolysis. Most important
2) Donor antibody + RBC recipient :arrow: Very minor, because the donor antibody is little, in blood tranfusion it is neutralized by the serum or endothelium of the recipient, it becomes important when you give alot blood in a donor of very small weight
Q1
AB people has no antibody against A & B :arrow:
reaction (1) does not happen :arrow: Universal recipient
Q2
in case of great transfusion for small weight people
Although AB group people can receive blood O, A, B group
But is is still better to receive AB group
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| jenni1
Forum Junior
Topics: 5
Posts: 12
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Thanks a lot!
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