phuluong2k
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Cytidine deaminase in tumor cells would inactivate cytosine arabinoside ( araC) to form which of the following compounds ?
a. Cytidine
b. Cytidyic acid
c. Cytosine
d. Thymidine arabinoside
e. Uracil arabinoside
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| lucky1
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its uracil arabinoside
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| ssrpk
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e. Uracil arabinoside
___________________
life is guud
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| usmlerock
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uracil arabinoside
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| karusmle
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thank god i knew the answer for this ,its uracil
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| karusmle
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i mean uracil arabinoside
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| Belen
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PYRIMIDINES:
CYTOSINE, URACIL, THYMINE: CUT
1 ring
CYTOSINE (NH2-)>>Deamination>> ;URACIL>>
URACIL>>[colo r=#6600cc]Methylation>>THYMINE (CH3-)[/color]
CYTARABINE,[/fon t] antineoplastic drug, will be deaminated in the body as a normal way of elimination which will no longer have antineoplastic effect.
CYTARABINE >>deaminates into>> Uracil arabinoside, which doesn't prevent DNA synthesis
FOLATE is responsible for the METHYLATION REACTION in purines and Pyrimidines
Some anti-cancer drugs will interfere with Methylation of Uracil into Thymine.
DHFR Dihydrofolate Reductase Inhibitor[font=Tahoma] like METHOTREXATE prevents the methylation of U by preventing FOLATE from giving the methyl group.
Edited by Belen on 06/06/05 - 11:52 PM
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