dream
Forum Newbie
Topics: 4
Posts: 12
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cud anybody tell wht enzymes r elevated during first few hrs after MI..
and later which enz?
thanks
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| rm
Forum Senior
Topics: 16
Posts: 77
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troponin I & T are elevated by 3-6hrs after MI and peak around 16hrs. stays elevated by for about 10days.
CK-MB are elevated by 4-8 hrs and peak by 18hrs.
LDH are elevated by 24 hrs and peak by 3-6 days.
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| syeruq
Forum Newbie
Topics: 2
Posts: 14
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also AST arises in very initial MI injury and we can diff. b/w liver injury and cardiac injury by this enzyme......as ALT is also increased with AST in liver while in cardiac it is not......
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| syeruq
Forum Newbie
Topics: 2
Posts: 14
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sorry not arises but increased.......
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Far better it is to dare mighty things, to win glorious triumphs, even though checkered by failure, than to take rank with those poor spirits who neither enjoy much nor suffer much, because they live in the gray twilight that knows not victory nor defeat.
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| ureterpolyp
Topics: 2
Posts: 77
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http://www.emedicine.com/emerg/topic327.htm
Lab Studies:
Creatine kinase–MB (CK-MB)
This is the criterion standard for detection of myocardial necrosis.
Levels begin to rise within 4 hours after injury, peak at 18-24 hours, and subside over 3-4 days.
Upper limit of reference range values for CK-MB is 3-6% of total CK.
A level within the reference range in the ED does not exclude the possibility of myocardial necrosis.
A single assay in the ED has a sensitivity of 34%.
Serial sampling over periods of 6-9 hours will increase the sensitivity to nearly 90%.
Over 24 hours, the sensitivity is near 100%.
Myoglobin
This is a very sensitive early marker of acute myocardial necrosis, but it is not specific for myocardial cell necrosis.
The myoglobin/carbonic anhydrase III ratio increases specificity. Myocardial cells do not release carbonic anhydrase.
Troponin I
This is a contractile protein that normally is not found in serum. It is released only when myonecrosis occurs.
For early detection of myocardial necrosis, sensitivity of this study is superior to that of the CK-MB. Troponin I is detectable in serum 3-6 hours after an AMI, and its level remains elevated for 14 days.
Troponin T has similar release kinetics and specificity for myocardial necrosis, but it is slightly less sensitive than troponin I within the first 6 hours.
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