drshabs
Forum Elite
Topics: 61
Posts: 205
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why patient with c-11hydroxlase deficiency has hyperkalemia?
there is increase 11-deoxycorticosterone(mineralocorticoid) which should cause hypertension and hypokalemia
:cry:
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| Dot
Forum Senior
Topics: 1
Posts: 168
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may be the enzyme def.is due to primary adrenal enzyme difficiency
[primary hypoaldosteronism]-But in that case chances of def. of 21-hydroxylase is more
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have fun
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| ayeshah_l
Forum Elite
Topics: 29
Posts: 284
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hope the following extracts help clear up ur concept. Details can be found at
http://www.emedicine.com/med/topic379.htm
Patients with 11-beta-hydroxylase deficiency present with features of androgen excess, including masculinization of female newborns and precocious puberty in male children. Approximately two thirds of cases also have hypertension, which may or may not be associated with mineralocorticoid excess, hypokalemia, and metabolic alkalosis
Salt-wasting
Salt wasting is a rare, but distinct, presentation.
Patients present with hyperkalemia, hyponatremia, and hypovolemia.
The exact pathophysiology is unclear, but it may be precipitated by glucocorticoid therapy.
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| drshabs
Forum Elite
Topics: 61
Posts: 205
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thanks!!
GL
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