ayeshah_l
Forum Elite
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how will u diagnose a case of CLL?
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| mash
Forum Fanatic
Topics: 147
Posts: 1,326
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>60 y/o pt with painless generalized LAP or
asymptomatic pt with elevated WBC count
diff --80-98% lymphocytes
PBS--smudge cells
BM <20% blasts(replaced with small lymphocytes)
to confirm the dx --> peripheral bld flow cytometry--CD19+ve (or coexpression of CD 19 and CD5) B cells
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I hear and I forget. I see and I remember. I do and I understand.
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| ayeshah_l
Forum Elite
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is there a role of lymphnode biopsy?
what is LAP?
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| mash
Forum Fanatic
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LAP is leukocyte alkaline phosphatase and is present in granulocytes..
malignant granulocytes lack it
its increased in leukemoid reaction and decreased in CML(though 75-95% cells are granulocytes)
CLL is malignancy of naive B cells so, i dont think l node bx wud help in the dx..
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I hear and I forget. I see and I remember. I do and I understand.
--Confucius
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| ayeshah_l
Forum Elite
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thanks mash, i came across a Q in UW about CLL and i picked BM biopsy and they said its the wrong answer as the tap will be dry!!! :?: and that in CLL node biopsy is always the correct answer!! :icon_scratch:
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| mani
Forum Guru
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i think the option that said that tap will bdry would have been about FNAC, not LN biopsy as there is no tap in LN biopsy
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| mash
Forum Fanatic
Topics: 147
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lymph node biopsy is indicated if lymph nodes begin to enlarge rapidly in a patient with known CLL to assess the possibility of transformation to a high-grade lymphoma.
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I hear and I forget. I see and I remember. I do and I understand.
--Confucius
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