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Author7 Posts
  #1

Aspirin is a weak organic acid with a pKa= 3.5. What a percentage of a given dose will be in the lipid soluble form at a stomach pH 2.5?

  #2

10%

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  #3

answer: is 90%. but how?

  #4

My MISTKAKE , I had it the opposite way which is WRONG.Only the nonionized form,which is uncharged and LIPOD soluble crosses boundaries.

pH-pKa -2 -1 0 +1 +2 pH-pKa= x
weak
acid%non 2.5-3.5= -1
ionized 99 90 50 10 1

At-1 90% is in lipod form

I apologize

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Smell the coffee! "Is That an Osler move??"

  #5

yes, thanks
but how did you calculate?
you told me the possible answer 99- 90-.... and logic how did you find the correct answer 90?

  #6

how'd u get that?

  #7

Kaplan has a wonderful table about this. I know we should be able to calculate this using the Henderson-hasselbalch equation but in the exam, I wouldn't like to have to calculate too much. So I just try to remember the figures.
Absorbed form is the non ionized one ( weak acid or weak base)

pH - pKa= -2 ; -1; 0; 1; 2 correspond respectively to unionized form of
weak acid 99%; 90%; 50%; 10%; 1% and the opposite with
weak base 1%, 10%; 50%; 90%; 99%.
Weak acid + weak base = 100%

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