SDK
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A 1500milimicro: of albumin labeled with radioactive iodine is injected I/V in normal adult male..There is complete mixing in the plasma without excretion.....What will be the plasma albumin conc: after 10 min: of injection???
a)300
b)500
c)450
d)350
e)1500
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| merrk
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a?
a knee jerk response
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| SDK
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The answer is B....
C=A/V
C: concentration
A: Amount of tracer
V: volume
C=1500/3L=500.
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| ssrpk
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why do u suppose tht plasma volume will still be 3 L ,shud'nt tht expand as albumin infusion increases the oncotic pressure.
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| lucky1
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hi,
sorry i didn't get the answer please can u explain me.
how do u got the value of 3 liters.
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| SDK
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I got 3 ltr as volume of plasma.....
ECF=14 lt
ICF=28 lt
plasma=3 ltr(part of ECF)....
I read this Qs from kaplan in which value was given as 900 mu & answer is 300...So I just change the value as 1500(500)...There is no clear cut description is given in the kaplan.... 8)
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| ssrpk
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i agree......oncotic pressure won't hv much effect in terms of plama volume expansion in just 10 minutes!
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| aim
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from where u got ECF&ICF,I THINK SINCE IT IS ATTACH TO ALBUMIN & NOT EXCREATEDSO VALUE WILL REMAIN SAME
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| NE
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You have to calculate TBW - 60% of 70 kg ( you have to assume this weight because is a "standard" weight and the stem q doesn't tell you anything about this), and after that plasma volume represents 1/12 of TBW.
Vol distribution (plasma vol) = Amount subst./conc
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