doc2003
Forum Senior
Topics: 35
Posts: 58
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A 5yo boy with a history of recurrent ear infections receives his preschool booster immunization against diphthena-tetanus-pertussis He is participating in a community-sponsored study to determine the humoral immune response to tetanus toxoid (tt) His response is well below normal for age- and sex-matched children Peripheral B lymphocyte count and T lymphocyte count and function are within the reference range The antibody he makes is positive in both the passive hemagglutmation and complement-mediated lysis of tt-coated erythrocytes His antibodies do not opsonize tt-coated latex particles for phagocytosis and do not directly precipitate tt efficiently This child most likely has a defect in which of the following processes'?
A) Affinity maturation of immunoglobulms
B) Immunoglobulm isotype switching
C) Recombination of heavy chain variable region genes
D) Recombination of light chain variable region genes
E) Somatic mutation of immunoglobulm genes
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| step1doc
Forum Newbie
Topics: 6
Posts: 37
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hi,
could u please post the answer if u know it.thank you.
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| phuluong2k
Forum Fanatic
Topics: 714
Posts: 2,008
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i think the answer is B, he only make IgM,
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