SDK
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65)The Coronary Drug Project was a randomized trial to evaluate the efficacy of several lipid-lowering drugs. The five-year mortality of the men who adhered to the regimen of clofibrate (i.e., took 80% of their medicine or more) was 15%; among
those assigned to the clofibrate group who were less compliant, it was 24.6%. The result was highly statistically significant (p < 0.0001). From this one can conclude
a. Clofibrate was very beneficial to the patients who took it reliably
b. Clofibrate is not effective unless patients take at least 80% of the recommended doses
c. Either clofibrate or something associated with taking it reliably is strongly associated with reduced total mortality
d. There was a problem with blinding in this study
e. Only those who were compliant should be included in the data
f. A correlation study with a small number of countries
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| lucky1
Forum Newbie
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hi i think the answer is C
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| knasim
Forum Junior
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what about e?
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| 99doc
Forum Elite
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it can't be e.as we will have totally different study group then.
i feel c is correct.
it clearly shows that the compliant group had reduced mortality with statistically significant results.
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| mjl1717
Forum Hero
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Im torn between c and d but Ill go with d
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| ssrpk
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well the main problem with this study design is tht there is nop control group to compare to......and this study was basically to test efficay not compliance!
besides this seems to be a community trial .....tht's why compliance is a factor so no blinding strategy required.....
i'll go with c!
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