ssrpk
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B) IgE
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hey i didnot notice the typo,one of the choices given was IgM...
do you still stand with IgE?????
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| ssrpk
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well i think i will still go with IgE because in atopy(Type I) the primary response to antigen doesa'nt manifest itself as severly as does the interaction of antigen with IgE on subsequent exposure.......but tht's the way i think!
if the givn answer is IgM ,plz clearify the reasoning as well!
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hi
this Q is from Q-bank and i chose the answer to be IgE.but the answer was givern as IgM...and the reasoning they provided was ....
in anytype of reaction the first immunoglobulin produced is IgM.i was not satisfied by the answer.in type 1 hypersensitivity the immunoglobuolin produced is IgE ...rt?
can you please clarify it for me?
thanks
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| ssrpk
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well first of all it's correct tht IgM is th first synthesized antibody but after class switching has occured ,the spliced exons are discarded particulrly in case of atopy and has rearrangement of exons for IgE ....... so tht on subsequent exposure to tht particular allergen IgE will be synthesized not IgM.....
but in this clinical presentation.....is it really signifying some allergic reaction like anaphylaxis.....because if it's not atopy then definitely IgM will be produced first...
wht do u say?
:shock:
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hi
what you have told is correct.but the usual thing in books is that the anphylactic reactions are mediated by IgE...rt?
does class switching occur in anaphylactic reactions?
donno i'm confused by this answer.....
i wud still go with IgE....
so you would say that its IgM?????
thanks a lot for your contribution...
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| ssrpk
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no u are abosulutely rite and i am still wil IgE......thing is this is a bad examle of testing tht initial IgM reponse to an antigen,because things are mixing ovr here with allerguic reaction!
in anaphylactic reactions it is deinitley IgE ..... nd abt this class switching it occurs after IgM is synthesized during primary exposure...remember if no IgE were synthesized no such allergic reactins because IgE attaches to mast cells which gets degranulated after it's interction with the allergen......which in normal individuals will not elicit such a response(no IgE)
:? IgM seems confusing regarding the clincal scenario
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hey thanks a lot once again......
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| aahy1978
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hey, i think i remember doing that question on QBank as well and i felt like it was kind of tricky of them... but the first portion of the question is a distractor, the question is simply what is the primary Ig that responds to any antigen. I think if u go back to the original question and just read the last sentence, u'll see what i'm talking about... i am pretty sure the question was something along the lines of the first or primary Ig present.
anyway, i hope that helps
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hi
can you more specific...plz?
thanks...
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