hypersensitivity????

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hypersensitivity????

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7 Posts

saba_03

Topics: 18
Posts: 59

03/24/05 - 09:06 AM

chronic rejection in transplant recepients.which type hypersensitivity?

phuluong2k
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Topics: 714
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03/24/05 - 10:00 AM

Type IV

saba_03

Topics: 18
Posts: 59

03/24/05 - 11:12 AM

can u explain y ?cuz it says anitibody mediated vascular damage(fibrinoid necrosis)in FA which is type III-thanx in advance

dollios
Forum Newbie

Topics: 3
Posts: 27

03/24/05 - 05:04 PM

hyperacute rejection= Preformed Ab against transplant = type 2
acute rejection= t-cell mediated CD8= type 4
chronic rejection= Ab+C* deposition in vessels= type 3

i had the same question so i looked them up in an immunology text book (Ivan Roitt), and i read somewhere that hyperacute is a localized arthus rejection (Type 3) but i think Roitt's is more reliable.

saba_03

Topics: 18
Posts: 59

03/25/05 - 08:05 AM

thanx

ssrpk
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03/28/05 - 05:45 AM

"dollios" wrote:

chronic rejection= Ab+C* deposition in vessels= type 3
.

whtz C*????
plz elaborate a bit....which antigens wud be involve in forming compexes and then further get deposited in he vessels!!!!!

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dollios
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Topics: 3
Posts: 27

03/28/05 - 10:37 AM

Roitt's 9th edition p359:
"Insidious and late rejection is associated with subendothelial deposits of Immunoglobulin and C3 on the GBM which may sometimes be an expression of an underlying immune complex disorder ( originally necessitating the transplant) or possibly of complex formation with the soluble antigens derived from the grafted kidney"

I'd just stick to the last post :wink:

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