mjl1717
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Name 7 things that make the O2/hemogobin disassociation curve shift to the right.
(drop off O2 or hypoxic state)
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| ssrpk
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inc. H+
inc PCO2
inc 2,3,DPG
inc temperature
hyperthyroidism
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| nyimg
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plus residing at high altitude...or adaptation to any chronic hypoxemia
exercise (increasing T, CO2 and low PH)
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| ssrpk
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why wud high altitude leads to rightward shift??
initially there will be hyperventilation in terms of PCO2(decreases) in inorder to correct the decrease in PO2 by inc. alveolar ventilation! This will increase the blood pH .....later on secondary polycythemia occurs which corrects the oxygen deficit (amount delivered,not the PO2) and kidney compensates for the inc in pH by excreting excess HCO3- which eventually returns the pH back to normal!
so only in the initial phase there will be shift in oxy-Hb curve towards the left [increase in pH]
besides PO2 by itself do not directly affect the oxy-Hb curve!
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| mjl1717
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ssrpk-That was a good extrapolation with the hypethyoidism(a hyper metabolic state) so exercise is definitely included.
Is not hyperventilation a hypermetabolic state? I know high altitude(respiratory alkalosis) would be included! Not sure exactly why. With your help and nyimg's help we kind of beat this into the ground. 
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| nyimg
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The reason for shifts to right for high altitude is due to the adaptative increase of 2,3-DPG. 2,3-DPG binds to hemoglobin b-units and causes thehemoglobin-o2 dissociation curve shift to the right to improve unloading of o2 in the tissues
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| ssrpk
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hmmmmmm nyimg...
i think i agree....can ya plz elaborate it little bit more....!
why does 2,3 dpg increases?
thx
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| ssrpk
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nyimg tht's a guud point u made!
i just chked it out ..... pH increases when residing at high altitude.....which stimulates glycolysis :arrow: increase 2,3DPG ....curve shifts to the right!
so to complete the picture.....it's pH change tht changes 2,3 DPG!
to mjl,
hyperventilation :arrow: decrease in PCO2 which inc. pH
hypermetabolic state :arrow: inc. production of CO2
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| manojmazumder
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Chronic anemia would also shift the curve to the right.
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| mjl1717
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Good, anyone agree wih this last comment??
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| ssrpk
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anemia by itself or polycythemia.....these factors by themselves only affect the overall O2 carrying capacity of the blood....but P50 remains the same.......
however as he mentioned chronic anemia...then because of tissue hypoxia the P50 increases agauin due to inc in our l'll friend 2,3 DPG which increases the delivery of O2 to the tissues.....pretty kool huh!
q-wht will happen to O2-Hb curve if packed RBC's are stored for long period of time in vitro?
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| manojmazumder
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The curve will shift to the left as 2,3DPG will reduce
Manoj
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| ssrpk
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correct 8)
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