phuluong2k
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In FA page 156
Fructose intolerance
Fructose 1 phosphate accumulates, causing a decrease in available phosphate; which results in inhibition of glycogenolysis and gluconeogenesis.
Please explain mechanism of inhibition of glycogenolysis and gluconeogenesis.
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| Remy
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Normally the phosphate that is obtained by cleaving fructose 1 p into dhap and glyceraldehyde is used in gluconeogenesis and glycogenolysis.
In glycogenolyis the enzyme glycogen phosphorylase needs a phosphate to convert glycogen into glucose 1 phosphate.
In gluconeogenesis the free glycerol that enters the liver from break down of fat in adipose tissue needs to become glycerol 3 phosphate so there we need more phosphates.
so as fructose accumulates, all the phosphate is stuck there because all the phosphate has been used up to convert fructose to fructose 1 phosphate and there is nothing left for these two pahtways.
Rememeber phosphate is needed to convert glyceraldehyde 3 phosphate to 1,3 bis phospho glycerate in glycolysis so when there is no phosphate no 1,3 bisphospho glycerate so no glycolysis so no atp so the liver swiches to glycogenolysis and gluconeogenesis but those pathways are also inhibited .
This is what I think. hope this helps
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| phuluong2k
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Thanks
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