vmatveev
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Does anybody know the exact mech of hypokalemia in aspirin toxicity?
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| SDK
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There are posibilties of hypokalemia in aspirin toxicity.....Metabolic Alkalosis.
1)Shift of K into cells.....H+ out of cell.
2)Loss of K....Vomiting
3)HCO3 loss in urine....K loss.
Apirin initially cause metabolic alkalosis.....vomiting.....loss of Hcl----alkalosis.this produce above effects.
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| SDK
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There are three posibilties of hypokalemia in aspirin toxicity.....Metabolic Alkalosis.
1)Shift of K into cells :arrow: H+ out of cell.
2)Loss of K. :arrow: Vomiting
3)HCO3 loss in urine :arrow: .K loss.
Apirin initially cause metabolic alkalosis. :arrow: vomiting. :arrow: .loss of Hcl- :arrow: alkalosis.this produce above effects. 8) :lol:
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| phuluong2k
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Aspirin first cause respiratory alkalosis, later metabolic acidosis
http://www.gpnotebook.co.uk/simplepage.cfm?ID=-14...
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| SDK
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I agree with u this is my mistake... 
So Is hypokalemia due to respiratory alkalosis :?:
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| vmatveev
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Aspirin toxicity first elicits respiratory alkalosis, kidneys then dumped HCO3 in the urine trying to compensate for respiratory alkalosis. During that there is a shift of K into cells with increased elimination in the urine. Then due to severe uncoupling in respiratory chain, metabolism is accentuated on anaerobic glycolysis with consequent metabolic lactic acidosis with large anion gap. But the acidosis is the last stage of aspirin poisoning, so probably there is a condition characterized by lack of potassium developed during respiratory alkalosis.
Any comments?
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| SDK
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That is nice info..... 8)
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| ssrpk
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why does loss of HCO3 results in K+ loss in the urine?
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| SDK
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There is unclear mechanism written in the books........
But books write that K loss occur with HCO3,penicillin,PO4 in urine........ :?:
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| ssrpk
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well it;'s not K+..........Na+ and H2O are losty equally.......is it due to osmolality effct of maybe higher tubular flow....???????????/
this mech. is really not clear in the books.....
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