phuluong2k
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By which mechanism does cortisol cause hypocalcemia & hypokalemia
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| ssrpk
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cortisol does not directly causes hypokalemia in physiological range , however at high levels it has significant mineralocorticoid activity to induce salt&water retention and causing hypokalemic alkalosis
similarly at high levels only....it has been hypothesized tht it may reduce the absorption of Ca++ from gut and increase their excretion into the urine :arrow: secondary hyperparathyroidism....in addition it also has osteoblast inhibiting activity.
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| phuluong2k
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Thanks, very good explanation
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