r753_2000
Forum Elite
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A woman who recently migrated from Italy brings in her daughter, age 9 months, for checkup. You noticed that she has jaundice. Physical exam revealed hepatosplenomegaly. Labs were performe and revealed microcytic anemia with normal iron studies. What is the pathogenesis of her disease?
a) gene deletion
b) defective mRNA processing
c) mutation
d) amino acid substitution
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| lucky
Forum Guru
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gene deletion?
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| ELM
Forum Guru
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B tal is she has, so the cause is mutations.
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ELM
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| tamriko
Forum Elite
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B.
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| r753_2000
Forum Elite
Topics: 59
Posts: 255
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The answer is B. A defect in mRNA processing causes B-Thal.
Gene deletion is the cause in A-thal.
Amino acid substitution is the cause of sickle cell anemia.
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