dimps
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Difference between secretory & osmotic diarrhoea
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| dacis
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Secretory diarrhea - increased secretion of fluid and electrolytes ( may be caused by activation of adenyl cyclase-cAMP system ) or decreased absorption .
Adenyl cyclase-cAMP system is activated by cholera toxin , E. coli toxin , Salmonella enterotoxin and VIP .
Osmotic diarrhea - caused by nonabsorbable substance in the lumen of intestine with secondary accumulation of fluid .
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| mash
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and
-osmotic diarrhea stops on fasting but secretory does not
-osmotic gap is >50 in osmotic diarrhea and nl in secretory.
[osmotic gap is measured osmolality - calculated osmolality]
calculated osmolality-- 2(Na + K)
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