SDK
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Good evening(in my zone) everybody.
In Turner syndrome pts have short stature while in klinfelter syndrome they have tall stature. Why?? :?: :?: :?: :?:
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| mdwannabe
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Estrogen needed for both for growth and for fusion of growth plates. However, it is testosterone that fuses plates. Hence, In Turner, no estogen, no growth. In Klein no testosterone so growth goes on. Ofcourse it is more complicated than that, but it should do for now.
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| SDK
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As u wrote estrogen is necessary for growth & fusion of growth plate.
In turner----dec: estrogen----dec growth & late fusion of growth plate---tall stature.Am I write with ur explanation?
In klinfelter, dec: testosterone---late fusion of grwth plate----tall stature.
Then how Turner women have short stature?
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| mdwannabe
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That is why I said it is more complicated... Estrogen does not only causes fusion, it is need for growth. In Turner there is no estrogen, so growth is minimal. But Estrogen is not the only hormone involved in growth, you got GH, Insul-lk GH, T3, T4 etc... all of that is involved. So in Turner you have some growth but not enough, mineralization is impared as well.
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| SDK
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Still i have confusion.
In normal female ht(rapid early fusion) is shorter then male. why?
only estrogen(androgen) or other hormones are also required?
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