phuluong2k
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Mutation in cystic fibrosis transmembrane conductance regulator (CTFR) protein alter which of the following ion transport mechanism?
a. Ca++-activated Cl- secretion
b. Ca++-activated Cl- uptake
c. cAMP-stimulated Na+ secretion
d. cAMP-stimulated Na+ uptake
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| anatomy
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"A"?
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| phuluong2k
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I don't know the answer
Any one can explain ?
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| phuluong2k
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Sorry all
I pick the q from a bad source  , so it not complete. I think this q is more complete
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein alter which of the following ion transport mechanisms?
A ) Ca2+-activated Cl– secretion
B ) Ca2+-activated Cl– uptake
C ) Cyclic AMP (cAMP)-stimulated Cl– secretion
D ) cAMP-stimulated Na+ secretion
E ) cAMP-stimulated Na+ uptake
My choice is C
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| ssrpk
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first of all its' transport is associated with cAMP and it even differs in different organs...eg. reabsorption is sweat glands and secretion across resp. tract epithelium.
Mutation disrupts the secretion in resp.tract epithelium leading to dehydrated mucin and it even causes sec. changes tht leads to inc. active reabsorption of Na+ which is followed by H2O contributing to the dehydration...
Considering Na+ dynamics in mind ....maybe answer is C.altered Na+ secretion
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