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Kaplan Qbank USMLE



Author12 Posts
  #1

A drug is given that producesvasodilatation by increasing cGMP in the smooth muscle cells of arterioles. Which of the following drugs has this mechanism of action?

A- Bethanechol
B- Isoperoteronol
C- Metaproteronol
D- Nifedipine
E- Phentolamine
F- Phenylephrine

  #2

D - nifedipine????

some indirect effect i guess

___________________
life is guud

  #3

No try again

  #4

isoproterenol?

___________________
life is guud

  #5

Phentolamine

  #6

plz explain , none of the abv listed drugs hv direct efffect on cGMP, thnx

___________________
life is guud

  #7

So I am wrong

  #8

A- Bethanechol - muscarinic

B- Isoperoteronol - beta agonist ... cAMP

C- Metaproteronol - beta agonist cAMP

D- Nifedipine - Ca channel blocker

E- Phentolamine - alpha blocker

F- Phenylephrine - Alpha agonist (DAG/IP3)

___________________
life is guud

  #9

yeah none
Im thinking of Viagra and Nitroglycerin

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Smell the coffee! "Is That an Osler move??"

  #10

hey kazem, plz answer....is there some indirect effect?

___________________
life is guud

  #11

pls kazem what is the answer?

  #12

the answer is A) Bethanecol, since it's an M3 cholinomimetic (agonist). It activates the release of NO from endothelial cells, which in turn activates guanyl cyclase, thus increasing cGMP.







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