neurite
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If the NADPH oxidase of PMN is deficient, should patients become more susceptible to catalase-negative organisms? Why does Kaplan biochemistry on page 202 claim that the patients are more sensitive to catalase-positive organisms? What's the logic here?
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| phuluong2k
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NADPH oxidase :arrow: O2 :arrow: O2°
Superoxide dismutase :arrow: O2° :arrow: H202
Myeloperoxidase :arrow: H202 :arrow: HCLO
Catalase positive (staph, ) :arrow: H2O2 :arrow: H20
Staph. produce catalase :arrow: breaks down endogenous hydrogen peroxide :arrow: disrupt the generation of oxygen radicals by a phagocyte oxidase system
So catalase is a protective enzyme of Staph. :arrow: most infection in CGD
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| phuluong2k
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Think that Staph. aureus (catalase positive) is More than dangerous, More toxic, More resistant to drugs than streptococcus (catalase negative) :arrow: More infection in CGD
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| neurite
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Well, I would think that cat- bacteria are mostly killed by ROS. If no ROS can be produced, these cat- are saved and so become more danderous. Cat+ are bad. But there being no ROS doesn't seem to make them more dangerous.
Unless that cat- guys don't play an important role in CGD at all.
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