phuluong2k
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In chronic anemia, why there is a fatty change of cardiac myocytes, renal proximal tubue cells, centrilobular hepatic cell ?
plz give me the explanation, thank
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| ssrpk
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fatty acid oxidation requires oxygen principally in heart and liver and especially during fasting when fatty acid uptake is high....(ketogenesis in liver and metabolic req. by heart)
chronic anemia :arrow: relatively low oxygen tension :arrow: low breakdown of fatty acid principally in liver and heart which undergoes fatty change :arrow: increase blood level of fatty acids (hydrolysis of TGs) :arrow: spill over in the urine :arrow: reuptake in the proximal tubule
plz correct
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