msashraf
Forum Senior
Topics: 7
Posts: 156
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in acute aspirin poisoning resp. alkalosis is primary bcos aspirin directly stimulates the respiratory center in brain. and in chronic aspirin poisoning there is metabolic acidosis due to accumultaion of salicylic acid.
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| ELM
Forum Guru
Topics: 28
Posts: 936
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According to my knowledge aspirin intoxication causes MIXED PRIMARY ACID BASE DISORDER. Aspirin directly stimulates respiratory center in brain stem causing hyperventilation and also causes anoin gap metabolic acidosis by adding ACAcid into the system........so these are both Primary Mixed disorders------> with normal Ph but the patient is severely ill. There is no compensation in here because Ph is normal, but everything is increased.
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ELM
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| noelle
Forum Elite
Topics: 59
Posts: 226
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so whats the metabolic picture!! if acute then primary met. acidosis + comp. resp alkalosis?? n chronic its pri. met. acidosis + prim. resp alkalosis?? ITS A UW Q!!
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| ELM
Forum Guru
Topics: 28
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I am sorry i don't understand your q.
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ELM
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| msashraf
Forum Senior
Topics: 7
Posts: 156
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aspirin causes hyperventilation by stimultaing resp.center and that causes resp.alkalosis. asp also uncouples oxidative phosphorylation that leads to increase in lactic acid levels. so the picture is that of mixed respiratory alkalosis and metabolic acidosis with anion gap.these 2 are caused by direct toxic effect of aspirin and are compensatory.
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