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clearance

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clearance
mjl1717
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Posted 01/23/05 - 06:48 AM:
Subject: clearance 		quote post
#1
The vol. of plasma from which x is removed over a period of time.

Mathematically its:= excretion x/Px=Ux times V/Px
{uv/p: is too easy to say!!}

Q?-Arrange the folowing substances from the greatest clearance to the
least clearance:
glucose, sodium, potassium, PAH, inulin, protein,
creatinine, urea, bicarbonate, Pennicillin, mannitol
Smell the coffee! "Is That an Osler move??"
phuluong2k
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Posted 01/23/05 - 09:18 AM:
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#2
Greatest: PAH




Lowest: Protein, Glucose
mjl1717
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Posted 01/23/05 - 10:07 AM:
Subject: q 		quote post
#3
You got 2 out of 11.
Under normal circumstances protein is NOT cleared at all!!!!!!!!!!!!!!
{There is is negative charge on the filtering membrane that inhibits the filtering of protein}
Thus its not filtered, not excreted, not secreted, mathematically clearance is ZERO,{normal kidneys}
Smell the coffee! "Is That an Osler move??"
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Posted 01/23/05 - 11:34 AM:
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#4
PAH greatest - renal plasma flow
inulin - GFR
b/w PAH nd inulin: creatinine
b/w inulin and glucose/protein: urea, potassium & sodium

wht about mannitol???
life is guud
mjl1717
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Posted 01/23/05 - 11:43 AM:
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#5
I do not understand.
Smell the coffee! "Is That an Osler move??"
phuluong2k
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Posted 01/23/05 - 11:44 AM:
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#6
Is Manitol cleacrance the same as that of inulin ?

In fact, glucose in low concentration :arrow: it is reabsorbed totally :arrow: Clearance = 0, but in very high concentration :arrow: Saturation of glucose transporter :arrow: The clearance approaches that of Inulin
mjl1717
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Posted 01/23/05 - 12:09 PM:
Subject: q 		quote post
#7
Like inulin mannitol is filtered but not reaborbed
hint:{The best way to do this q is to categorize everything}
Smell the coffee! "Is That an Osler move??"
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Posted 01/24/05 - 04:03 AM:
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#8
From greatest to smallest order

1 PAH

2 Creatinine

3 Inulin, mannitol

4 Sodium, potassium, Urea

5 Bicarbonate

6 Pennicillin

7 glucose, protein


MJL Plz correct my answer, thanks
mjl1717
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Posted 01/24/05 - 01:20 PM:
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#9
Thats basically correct.
Smell the coffee! "Is That an Osler move??"
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